Battles With Coalition of Villains

Throughout the five-year mission, the Enterprise encountered many Coalition of Villains ships and people. Several villainous commanders and leaders, including Commander Kor, General Grevious, Count Dooku, and evil Palpatine, held Enterprise in high professional regard, and relished the prospect of battle. Other villains, such as Darth Vader or Hacker mocked the ship and her crew, referring to her as "a pile of garbage" or a "worthless pieced-up craft"..

Following the outbreak of the Coalition-Republic Conflict in 2267, the Enterprise was immediately attacked by a Coalition dreadnought, but destroyed it with ease.

After defeating the dreadnought, the Enterprise assumed orbit over the planet Organia in the Star Trek dimension to secure it for the Republic. However, an massive Coalition invasion fleet of 80 Star Destroyers and 12 Super Dreadnoughts led by Darth Vader from his flagship, the Executor, drove the Enterprise away, forcing her to abandon Mr. Spock and Captain Kirk on the world. The Enterprise later returned with a Republic naval force of 140 warships and dreadnoughts and prepared to engage Vaders' fleet but the Organians, a race of extremely powerful omnipotent beings, ended the conflict (by paralyzing all the ships and soldiers of both fleets) and forced both sides to sign the Organian Peace Treaty.

A few months later, a Vampire Ghostship attempted to keep the Enterprise clear of Capella IV while Coalition agents subverted the natives and tried to gain access to a rare mineral, Capella. When the plan was unsuccessful, the ghostship engaged the Enterprise in combat and turned several Enterprise personnel into vampires. However, the Enterprise used a series of explosive antimatter charges to destroy the Ghostship and Dr. McCoy found a cure that can turn vampires back into humans.

The following year, the Enterprise was sabotaged by a Klingon agent who infiltrated the entourage of Harry Potter, a important Universal magician on visit to the Enterprise. The Enterprise was then attacked by a massive and extremely powerful Klingon vessel, which was equipped with a ion cannon and destructive dispersive cannons, but, with the aid of Potter, destroyed it and discovered the agent.

A few months later, the Enterprise was forced to destroy a abandoned Republic spaceship, the USS Vermont, which had been commanded by Captain Kang of the Star Trek dimension, since the ship had a threatening radiation shield. Kirk ordered the beaming aboard of the Republic-Klingon personnel of the ship. Under the influence of a extra-universal entity, the personnel tried to take over the ship. Kirk was able to stop them with Kang's help, and Dr. McCoy found a vaccine for their condition.