Picard's family line is through (Star Trek Generations)

In the captain's quarters, Captain Picard sits with his family photo album. Counselor Troi enters and he begins to tell her about his brother and nephew and his plans to get together with them on Earth the following month so he could show René Starfleet Academy. As he affectionately describes his nephew he breaks down and tells Troi that both Robert and René have burnt to death in a fire. Troi comforts him and Picard tells her that when he was growing up, he was always told about the Picard family line and his famous ancestors. When Robert got married and had a son he no longer felt the responsibility to carry on the family line and as he has got older and felt time creeping up on him he took comfort in the fact that his family would go on. But now it won't and once Jean-Luc is gone, there will be no more Picards.